NSK-SD® Nattokinase

NSK-SD^® Nattokinase FAQ's (Frequently Asked Questions)

1. What is NSK-SD^® Nattokinase and how does it work?

NSK-SD^® Nattokinase is a highly purified and standardized form of Nattokinase, which is an enzyme derived from fermented soybeans, particularly from the Japanese dish natto. It is known for its potential cardiovascular and circulatory health benefits.

NSK-SD^® Nattokinase works by breaking down fibrin, a protein involved in blood clot formation. This fibrinolytic activity promotes healthy blood circulation by preventing excessive clotting and may help reduce the risk of certain medical conditions.^†

2. Not all brands of Nattokinase are the same.  Why take the NSK-SD^® form of Nattokinase? 

- Is fermented using a patented strain of Bacillus subtilis natto

- Is non-GMO, vegetarian and non-irradiated

- Vitamin K2 has been removed and contains less than 1 ppm Vitamin K2 

- Has the highest proven potency of any vitamin K2 free Nattokinase on the market (> 20,000 F.U./gram).

The significance of removing vitamin K2 from Nattokinase can be understood in the context of how vitamin K2 and Nattokinase can affect blood clotting and cardiovascular health.

1. Blood Clotting: Vitamin K2 is a fat-soluble vitamin that plays a key role in blood clotting. It activates certain proteins in the body that help with blood clot formation. On the other hand, Nattokinase has been studied for its ability to break down fibrin, a protein involved in blood clot formation. By breaking down fibrin, Nattokinase may help prevent or may dissolve blood clots.^†
2. Blood Thinning: Nattokinase itself has blood-thinning properties, and some people take it to support cardiovascular health. If someone is already taking medications that affect blood clotting or has concerns about thinning their blood too much, they may choose a nattokinase supplement without added vitamin K2.^†

3. Avoiding Interactions: Vitamin K can interact with anticoagulant medications, affecting their effectiveness. Removing vitamin K from nattokinase supplements may be beneficial for individuals taking anticoagulant drugs, as it helps minimize the risk of interactions.^†

Key Points:

1. Improved Blood Circulation: Nattokinase is known for its ability to promote healthy blood circulation by breaking down fibrin, a protein involved in blood clot formation. This action may help prevent excessive clotting and improve blood flow, which may reduce the risk of conditions like deep vein thrombosis (DVT) and stroke.^†
2. Blood Pressure Regulation: Some studies suggest that Nattokinase may help lower high blood pressure. By inhibiting the angiotensin-converting enzyme (ACE), it can lead to vasodilation (relaxation of blood vessels), which may lower blood pressure and support overall cardiovascular health.^†
3. Reduced Risk of Cardiovascular Events: Improved circulation and lower blood pressure may reduce the risk of heart attacks, strokes, and other cardiovascular events, making Nattokinase a potential supplement for those concerned about heart health.^†
4. Anti-Inflammatory Properties: Nattokinase may have anti-inflammatory effects, which can benefit overall health. Chronic inflammation is linked to various health conditions, including heart disease and autoimmune disorders.^†
5. Improved Immune Function: While not a direct immune booster, better circulation and lower inflammation can indirectly support immune function. Efficient blood flow ensures that immune cells can reach infection sites more effectively.^†
6. Antioxidant Properties: Some studies suggest that Nattokinase may have antioxidant properties, helping to neutralize harmful free radicals and protect cells from oxidative damage.^†
7. Reduction in Blood Clot Risk: For individuals at risk of excessive blood clot formation, such as those with deep vein thrombosis or certain clotting disorders, Nattokinase may help reduce this risk.^†
8. Support for Overall Cardiovascular Health: By addressing factors like blood clotting and blood pressure, Nattokinase may contribute to better cardiovascular health and reduce the risk of heart-related conditions.^†
9. Covid-19 and Long Covid: The spike protein is a key component of the SARS-CoV-2 virus that causes COVID-19. It is responsible for allowing the virus to enter and infect human cells. Some researchers have hypothesized that Nattokinase may be able to break down the spike protein, rendering the virus unable to infect cells. There is also a suggestion that the mechanism contributing to Long Covid symptoms involves the obstruction of small blood vessels caused by the accumulation of tiny blood clots. Nattokinase is being considered for its potential antithrombotic properties in this context.^†

4. Is NSK-SD^® Nattokinase a prescription medication?

No, NSK-SD^® Nattokinase is not a prescription medication. It is available as a dietary supplement and can be purchased without a prescription. However, it's essential to consult with a licensed healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications.  Do not use this product if you are pregnant or breastfeeding, have a blood clotting disorder or are taking blood-thinning (anticoagulant) medication.  Discontinue use at least 2 weeks prior to undergoing surgery.  Not recommended for persons under the age of 18.

5. How should I take NSK-SD^® Nattokinase?

The recommended dosage of NSK-SD^® Nattokinase may vary among products and individuals. It's crucial to follow the dosage instructions and warnings provided on the product label or as advised by a licensed healthcare provider. Typically, it's taken with water on an empty stomach for better absorption.  Contains Soy.

References:

Takashi Tanikawa, Yuka Kiba, James Yu, Kate Hsu, Shinder Chen, Ayako Ishii, Takami Yokogawa, Ryuichiro Suzuki, Yutaka Inoue, and Masashi Kitamura, "Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2," Molecules 27, no. 17 (September 2022): 5405, https://doi.org/10.3390/molecules27175405

Oba, M., Rongduo, W., Saito, A., Okabayashi, T., Yokota, T., Yasuoka, J., ... Mizutani, T. (Year of Publication). “Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro. Biochemical and Biophysical Research Communications, Volume 570, 17 September 2021, Pages 21-25. https://doi.org/10.1016/j.bbrc.2021.07.034

Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Scientific Reports. 2015 Jun;5:11601. DOI: 10.1038/srep11601. PMID: 26109079; PMCID: PMC4479826.

Chen, H., McGowan, E. M., Ren, N., Lal, S., Nassif, N., Shad-Kaneez, F., Qu, X., & Lin, Y. (2018). Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights, 13, 1177271918785130. doi: 10.1177/1177271918785130.